English: Title: Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx - Mechanisms maintaining islet a-cell fate remain unclear. Studies by Chakravarthy et al
reveal mouse a-cell conversion into b-cells after Dnmt1 and Arx inactivation, suggesting
pathways to achieve b-cell regeneration. similar changes in subsets of islets in type 1
diabetes (T1D) suggests a molecular basis for a-cell dysfunction in T1D. Cell Metab. 2017 Feb 16; 25, 1- 13. [1]
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