File:SPPS.jpg
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This picture shows the coupling step in solid peptide synthesis. The picture was drawn according to a synthesis described by L. P. Miranda [1].
The amino acid chain AAHYHTHKE with side chain protecting groups is bonded with glutamate (E) to a PAM resin. For the next coupling step, lysine is shown close to the end of the chain. Lysine is protected with Boc (Nα) and 2-chloro-benzyl-oxy-carbonyl (sidechain). It is activated with OBt.
Colors
| green | resin |
|---|---|
| yellow | linker |
| red | peptide main chain |
| orange | peptide side chain |
| light blue | side chain protecting groups |
| blue | Boc group |
| magenta | activating OBt group |
References
- ↑ Miranda, L. P. et al. 2001. Total chemical synthesis and chemotactic activity of human S100A12. FEBS Letters 488 85-90
Summary
| Description | Ball and stick visualisation of a solid phase peptide synthesis |
| Date | |
| Source | own work (drawn in PyMOL) |
| Author | Felix Plasser |
Licensing
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 13:31, 11 August 2006 | | 597 × 544 (88 KB) | FelixP~commonswiki | {{Information |Description=Ball and stick visualisation of a solid phase peptide synthesis |Source=own work (drawn in PyMOL) |Date=2006-08-11 |Author=Felix Plasser }} |
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