Fujimoto–Belleau reaction

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The Fujimoto–Belleau reaction is a chemical reaction that forms cyclic α-substituted α,β-unsaturated ketones from enol lactones. The reaction is named after the two chemists George I. Fujimoto and Bernard Belleau.

The Fujimoto-Belleau reaction

The reaction is a Grignard reaction, followed by a H-shift, an enol-keto tautomerisation and an Aldol addition reaction. The last step is an elimination (Aldol condensation) reaction with an E1CB mechanism.

mechanism of the reaction

References[edit]