GW0742

GW0742
Clinical data
Pregnancy; category	N/A;
ATC code	None;
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid;
CAS Number	317318-84-6;
PubChem CID	9934458;
IUPHAR/BPS	2686;
ChemSpider	8110086;
ChEBI	CHEBI:156132;
ChEMBL	ChEMBL38508;
CompTox Dashboard (EPA)	DTXSID9040760 ;
Chemical and physical data
Formula	C21H17F4NO3S2
Molar mass	471.488 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c3c(F)cc(c1nc(c(s1)CSc2cc(c(OCC(=O)O)cc2)C)C)cc3;
	InChI InChI=InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28); Key:HWVNEWGKWRGSRK-UHFFFAOYSA-N;

GW0742 (also known as GW610742) is a PPARδ/β agonist^[2]^[3]^[4] that is investigated for drug use by GlaxoSmithKline.^{[citation needed]}

References

^ "Cayman Chemical GW0742". Retrieved 31 Mar 2013.
^ Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor ? Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.
^ Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research. 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.
^ Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.

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[1] "Cayman Chemical GW0742". Retrieved 31 Mar 2013.

[2] Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor ? Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.

[3] Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research. 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.

[4] Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.

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v t e Receptor/signaling modulators
Amino acids and similar/related	Amino acids and related: GABA receptor modulators GABA_A receptor positive modulators GABA metabolism and transport modulators GHB receptor modulators Glutamate metabolism and transport modulators Glycine receptor modulators Ionotropic glutamate receptor modulators Metabotropic glutamate receptor modulators Monoamines: Adrenergic receptor modulators Dopamine receptor modulators Histamine receptor modulators Melatonin receptor modulators Monoamine metabolism modulators Monoamine neurotoxins Monoamine releasing agents Monoamine reuptake inhibitors Serotonin receptor modulators hTAAR modulators Acetylcholine: Acetylcholine metabolism and transport modulators Muscarinic acetylcholine receptor modulators Nicotinic acetylcholine receptor modulators Others: Imidazoline receptor modulators Purine receptor modulators Sigma receptor modulators Thyroid hormone receptor modulators
Lipids	Eicosanoids: Cannabinoid receptor modulators Leukotriene signaling modulators Prostanoid signaling modulators Phospholipids: Lysophospholipid signaling modulators PAF receptor modulators Steroids: Androgen receptor modulators Estrogen receptor modulators Glucocorticoid receptor modulators Mineralocorticoid receptor modulators Progesterone receptor modulators Steroid metabolism modulators Other nuclear receptors: Aryl hydrocarbon receptor modulators Estrogen-related receptor modulators FXR and LXR modulators PPAR modulators Retinoid receptor modulators Vitamin D receptor modulators Xenobiotic-sensing receptor modulators
Peptides/proteins	Peptides: Angiotensin receptor modulators GH/IGF-1 axis signaling modulators GnRH and gonadotropin receptor modulators Melanocortin receptor modulators Neurokinin receptor modulators Opioid receptor modulators Oxytocin and vasopressin receptor modulators Cytokines: Cytokine receptor modulators Chemokine receptor modulators Interleukin receptor modulators TNF receptor superfamily modulators Growth factors: Growth factor receptor modulators TGFβ receptor superfamily modulators
Others and non-receptor	Enzymes: Cytochrome P450 modulators Histone deacetylase inhibitors Phosphodiesterase inhibitors Ion channels: Ion channel modulators TRP channel modulators Transporters: Sodium-glucose transporter modulators Symporter inhibitors Others: Nitric oxide signaling modulators

See also

References