Germline mosaicism

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Germline mosaicism, also known as gonadal mosaicism, is a condition in which the precursor (germline) cells to ova and spermatozoa are a mixture (mosaic) of two or more genetically different cell lines.

A study of semen samples from 100 men found low-level germline mosaicism in one third of infertile men, with increased incidence with advancing paternal age.[1]


  1. ^ Schiff JD, Luna M, Evans MI, Patel Z, Berry PK, Bar-Chama N (April 2010). "Sex chromosome micromosaicism in infertile men with normal karyotypes". Fertil. Steril. 93 (6): 1903–6. doi:10.1016/j.fertnstert.2007.11.094. PMID 20152966. 

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