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Gunn rat

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This is an old revision of this page, as edited by Tampasailor (talk | contribs) at 14:03, 18 September 2018 (→References: photos and details on Gunn Rat and CRIGLER-NAJJAR SYNDROME). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Dr. Charles Kenneth Gunn discovered a mutant rat in 1934 at the Connaught Laboratory in Toronto, Canada. These rats were jaundiced and the defect (a lack of the enzyme uridine diphosphate glucuronyltransferase) was transmitted as an autosomal recessive characteristic. Gunn, a geneticist, bred them at Connaught and later moved to Summerside, Prince Edward Island, Canada, to head up the Canadian Experimental Fox Ranch. This animal model has been extremely valuable for the development of experimental treatments for Crigler-Najjar syndrome.

CRIGLER-NAJJAR SYNDROME and the GUNN RAT== References ==

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