2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a

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2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a
Photochlor.png
Names
Other names
Photochlor
Identifiers
149402-51-7 N
Abbreviations HPPH
ChemSpider 4589621 YesY
Jmol-3D images Image
Image
PubChem 5488034
Properties
C39H48N4O4
Molar mass 636.84 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) is a photosensitiser chemical that is used in photodynamic therapy.[1]

It is being developed under the brand name Photochlor.

Clinical trials[edit]

A phase I/II clinical trial started in 1997 for esophageal cancer.[2]

A phase II trial for non-small cell lung cancer is due to run from 2007 to 2011.[3]

References[edit]

  1. ^ Lobel, J; MacDonald, IJ; Ciesielski, MJ; Barone, T; Potter, WR; Pollina, J; Plunkett, RJ; Fenstermaker, RA; Dougherty, TJ (2001). "2-1-hexyloxyethyl-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: implications for photodynamic therapy". Lasers in surgery and medicine 29 (5): 397–405. doi:10.1002/lsm.10001. PMID 11891727. 
  2. ^ Photodynamic Therapy Using HPPH in Treating Patients With Obstructive Esophageal Tumors
  3. ^ Photodynamic Therapy Using HPPH in Treating Patients With Advanced Non-Small Cell Lung Cancer That Blocks the Air Passages

External links[edit]