Hepatitis C virus cis-acting replication element
| Hepatitis C virus (HCV) cis-acting replication element (CRE) | |
|---|---|
 Predicted secondary structure and sequence conservation of HepC_CRE | |
| Identifiers | |
| Symbol | HepC_CRE |
| Rfam | RF00260 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | SO:0000233 |
| PDB structures | PDBe |
The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.[1]
See also
- Hepatitis C alternative reading frame stem-loop
- Hepatitis C virus 3'X element
- Hepatitis C virus stem-loop VII
- Hepatitis C stem-loop IV
References
- ^ You, S; Stump DD; Branch AD; Rice CM (2004). "A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication". J Virol. 78 (3): 1352–1366. doi:10.1128/JVI.78.3.1352-1366.2004. PMC 321395. PMID 14722290.
External links
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