Hepatotoxin
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.
It can be a side-effect of medication, or found naturally, as microcystins, or in laboratory environments.
The effects of hepatotoxins depend on the amount, point of entry and distribution speed of the toxin, and on the health of the person.
Hepatotoxic substances
- α-amanitin, a deadly cellular toxin found in Amanita phalloides mushroom (death cap)
- Aflatoxin
- Ethanol
- Halothane[1]
- Carbon tetrachloride
- Pyrrolizidine alkaloids, found in many plants in the Boraginaceae, Compositae, and Leguminosae families.
- Luteoskyrin
- allyl alcohol, amiodarone, Aroclor 1254, arsenic, carbamazepine, carbon tetrachloride, diethylnitrosamine, dimethylformamide, diquat, etoposide, indomethacin, methapyrilene, methotrexate, monocrotaline, and 3-methylcholanthrene.[2]
See also
References
- ^ Vardanyan, R. S., and Victor J. Hruby. Synthesis of Essential Drugs. 1st ed. Amsterdam: Elsevier, 2006. Print.
- ^ Waring, JF; Jolly, RA; Ciurlionis, R; Lum, PY; Praestgaard, JT; Morfitt, DC; Buratto, B; Roberts, C; et al. (2001). "Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles". Toxicology and Applied Pharmacology. 175 (1): 28–42. doi:10.1006/taap.2001.9243. PMID 11509024.
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