|Group:||Group IV ((+)ssRNA)|
Orthohepevirus is a genus of viruses assigned to the Hepeviridae family. Orthohepevirus is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometric capsids with a diameter of 27–34 nm. The type species is Orthohepevirus A, more commonly known as the Hepatitis E virus.
Orthohepevirus have RNA genomes of 7176 nucleotides in length and infect vertebrates. Additionally, the genome is monopartite, linear, and single-stranded. The genome is 5' capped with a poly A tail at the 3' end. The genome possesses three main open reading frames. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein.
Viruses from this genus have been isolated from birds and bats. The creation of new species within this genus to accommodate these viruses seems likely. At least three species of hepatitis E-like viruses have been isolated from birds.
A Hepatitis E-like virus has been isolated from a Swedish moose. This virus is quite distinct from the other known Hepatitis E viruses.
One study has suggested that this species may have originated in birds and then spread to bats and other mammalian species.
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- Drexler JF, Seelen A, Corman VM, Fumie Tateno A, Cottontail V, Melim Zerbinati R, Gloza-Rausch F, Klose SM, Adu-Sarkodie Y, Oppong SK, Kalko EK, Osterman A, Rasche A, Adam A, Müller MA, Ulrich RG, Leroy EM, Lukashev AN, Drosten C (2012) Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae. J Virol 86(17):9134-9147. doi: 10.1128/JVI.00800-12
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