Herbert W. Virgin

Herbert W. "Skip" Virgin
Born	Miami, Florida
Alma mater	Harvard University Harvard Medical School
Known for	Human virome Viral pathogenesis Autophagy
Scientific career
Fields	Virology Immunology Genetics
Institutions	Washington University School of Medicine
Doctoral advisor	Emil Unanue

Herbert W. "Skip" Virgin was the Edward Mallinckrodt Professor and Chair of the Department of Pathology & Immunology at the Washington University School of Medicine and a member of the National Academy of Sciences. He is best known for establishing murine norovirus as a model system for studying norovirus biology, for identifying host phenotypes associated with persistent viral infections, for defining alterations to the human virome in the context of different diseases, and for elucidating the roles of autophagy and interferon-stimulated genes during viral infection.

Life

Herbert Virgin was born in Miami, Florida and studied biology at Harvard University as an undergraduate, graduating magna cum laude. He obtained his M.D. and Ph.D. from Harvard Medical School, with his thesis work focusing on host immune responses to Listeria monocytogenes, and completed his residency in internal medicine at Brigham and Women's Hospital. Following post-doctoral training in the laboratory of Bernard Fields, he joined the faculty of the Washington University School of Medicine. He remained at Washington University until 2018, most recently as Chair of the Department of Pathology & Immunology. Virgin left St. Louis to enter the biomedical industrial sector, and was succeeded as chairman by Richard J. Cote.

Selected publications

• Barton, E; White, D; Cathelyn, J; Brett-McClellan, K; Engle, M; Diamond, M; Miller, V; Virgin, H (2007). "Herpesvirus latency confers symbiotic protection from bacterial infection". Nature. 447 (7142): 326–329. Bibcode:2007Natur.447..326B. doi:10.1038/nature05762. PMID 17507983. S2CID 4425405.
• Nice, T; Baldridge, M; McCune, B; Norman, J; Lazear, H; Artyomov, M; Diamond, M; Virgin, H (2015). "Interferon λ cures persistent murine norovirus infection in the absence of adaptive immunity". Science. 347 (6219): 269–273. Bibcode:2015Sci...347..269N. doi:10.1126/science.1258100. PMC 4398891. PMID 25431489.
• Orchard, R; Wilen, C; Doench, J; Baldridge, M; McCune, B; Lee, Y; Lee, S; Pruett-Miller, S; Nelson, C; Fremont, D; Virgin, H (2016). "Discovery of a proteinaceous cellular receptor for a norovirus". Science. 26 (6302): 933–936. Bibcode:2016Sci...353..933O. doi:10.1126/science.aaf1220. PMC 5484048. PMID 27540007.
• Norman, J; Handley, S; Baldridge, M; Droit, L; Liu, C; Keller, B; Kambal, A; Monaco, C; Zhao, G; Fleshner, P; Stappenbeck, T; McGovern, D; Keshavarzian, A; Mutlu, E; Sauk, J; Gevers, D; Xavier, R; Wang, D; Parkes, M; Virgin, H (2015). "Disease-specific alterations in the enteric viriome in inflammatory bowel disease". Cell. 160 (3): 447–460. doi:10.1016/j.cell.2015.01.002. PMC 4312520. PMID 25619688.