Histidine-tryptophan-ketoglutarate: Difference between revisions
m cleaning up links |
|||
| Line 42: | Line 42: | ||
== References == |
== References == |
||
{{No footnotes|date=April 2009}} |
{{No footnotes|date=April 2009}} |
||
1. Abou Abbass, A. et al, Biliary Complications After Orthotopic Liver Transplantation From Donors After Cardiac Death: Broad Spectrum of Disease, Transplantation Proceedings, Vol. 42, 3392-3398, Dec. 2010 |
|||
1. 510(k) Summary. Custodiol HTK Solution Common/Classification Name: Isolated Kidney Perfusion and Transport System and Accessories, 21 CFR 876.5880; Franz Kohler. Prepared December 14, 2004. [http://www.fda.gov/cdrh/pdf4/K043461.pdf http://www.fda.gov/cdrh/pdf4/K043461.pdf ] |
|||
2. Agarwal, A. et al, Comparison of Histidine-Tryptophan Ketoglutarate and University of Wisconsin Solutions as Primary Preservation in Renal Allografts Undergoing Pulsatile Perfusion, Transplantation Proceedings, 37, 2016-2019 (2005) |
|||
2. Ringe B.,et al. Safety and efficacy of living donor liver preservation with HTK solution. Transplant Proc. 2005;37:316–319. |
|||
3. Agarwal, A. et al, Organ Preservation With Histidine-Tryptophan Ketoglutarate Solution in Clinical Pancreas Transplantation: An Update of the Indiana University Experience, Transplantation Proceedings, 40, 498-501 (2008) |
|||
3. Agarawal A., et al. Follow-up experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation Transplant Proc. 2005;37:3523–3526. |
|||
4. Anaya-Prado, R. et al, Scientific basis of organ preservation, Current Opinion in Organ Transplantation, 2008 13:129-134 |
|||
4. Pokorny H., et al.: Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation — a prospective multi-centre observation study. Transpl Int. 2004;17:256-60. |
|||
5. Becker, T. et al, Pancreas Transplantation with Histidine-Tryptophan-Ketoglutarate (HTK) Solution and University of Wisconsin (UW) Solution: Is There A Difference?, Journal of the Pancreas, Vol. 8, No. 3, May 2007 |
|||
5. de Boer J., et al.: [[Eurotransplant]] randomized multicenter kidney graft preservation study comparing HTK with UW and Euro-Collins. Transpl lnt. 1999;12:447-453. |
|||
6. Botta, L., et al, Cardiac transplantation with a donor hear rescued from deep hypothermia, The Journal of Heart and Lung Transplantation, Vol. 30, No. 10, October 2011, 1203-1204 |
|||
6. Hesse U.J., et al.: Organ preservation with HTK and UW solution. Pabst Sci. Publishers, D-49525 Lengerich, 1999. |
|||
7.Chok, K.S.H. et al, Bile Duct Anastomotic Stricture After Adult-to-Adult Right Lobe Living Donor Liver Transplantation, Liver Transplantation, 17:47-52, 2011 |
|||
7. Hatano E., et al.: Hepatic preservation with histidine-tryptophan-ketoglutarate solution in living related and cadaveric liver transplantation. Clin Sci. 1997;93:81-88. |
|||
8. Cui, D.X. et al, Effect of Different Bile Duct Flush Solutions on Biliary Tract Preservation Injury of Donated Livers for Transplantation, Transplantation Proceedings , Vol 42. 1576-1581, June 2010 |
|||
9. Cywinski, J. B. et al, Association Between Donor-Recipient Serum Sodium Differences and Orthotopic Liver Transplant Graft Function, Liver Transplantation 14:59-65, 2008 |
|||
10. De Vera, M.E. et al, Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center, American Journal of Transplantation 2009, 9: 773-781 |
|||
11. Feng, X.-N. et al, Current status and perspective of liver preservation solutions, Hepatobility Pancreat Dis Int, Vol. 5, No. 4, November 15, 2006 |
|||
12. Fridell, JA, et al, Clinical experience with histidine-tryptophan-ketoglutarate solution in abdominal organ preservation: a review of recent literature, Clinical Transplantation, 2008 DOI 10.1111/j.1399-0012 |
|||
13. Fridell, J.A. et al, Histidine-Tryptophan-Ketoglutarate for Pancreas Allograft Preservation: The Indiana University Experience, American Journal of Transplantation, 2010, 10: 1-6 |
|||
14. Gkouziouta, A. et al, Heart Transplantation in a Low-Organ-Donation Environment: A Single Center Experience, Transplantation Proceedings, 41, 4289-4293 (2009) |
|||
15. Lee, S. et al, Superior myocardial preservation with HTK solution over Celsior in rat hearts with prolonged cold ischemia, Surgery (2010), 148:463-73 |
|||
16. Lynch, R. J. et al, Comparison of Outcomes with HTK and UW Solutions in Renal Transplantation, American Journal of Transplantation, 2008, 8: 1958 |
|||
17. Maheshwari, A. et al, Biliary Complications and Outcomes of Liver Transplantation from Donors after Cardiac Death, Liver Transplantation, 13:1645-1653, 2007 |
|||
18. Mangus, R., et al, A Comparison of Histidine-Tryptophan-Ketoglutarate and University of Wisconsin Solutions in Bowel Transplantation, Abstract, Transplant International, Vol. 20, Supplement 2, September 2007 |
|||
19. Mangus, R. S. et al, Comparison of Histidine-Tryptophan-Ketoglutarate Solution and University of Wisconsin Solution in Extended Criteria Liver Donors, Liver Transplantation, 14: 365-373, 2008 |
|||
20. Mangus, R., et al, Comparison of Histidine-Tryptophan-Ketoglutarate Solution and University of Wisconsin Solution in Intestinal and Multivisceral Transplantation, Transplantation, Vol. 86, Number 2, July 27, 2008 |
|||
21. O’Callaghan, J.M. et al, Preservation Solutions for Static Cold Storage of Kidney Allografts: A Systematic Review and Meta-Analysis, American Journal of Transplantation, October 2011. |
|||
22. Schneeburger, S. et al, A prospective randomized multicenter trial comparing histidine-tryptophane-ketoglutarate versus University of Wisconsin perfusion solution in clinical pancreas transplantation, Transplant International, 2008, 9:1-8 |
|||
23. Schneeberger, S. et al, Atypical Acute Rejection After Hand Transplantation, American Journal of Transplantation 2008, 8: 688-696 |
|||
24. Simoes, E.A., et al, Comparing the Performance of Rat Lungs Preserved for 6 or 12 Hours After Perfusion With Low Potassium Dextran or Histidine-Tryptophan-Ketoglutarate, Transplantation Proceedings, 43, 1520-1524 (2011) |
|||
25. Sucher, R. et al, Investigation of the Role of Ischemia and Reperfusion in Limb Transplantation, American Transplant Congress 09, Boston, MA, Abstract 1062, (May 31, 2009) |
|||
26. Tellioglu, G. et al, Histidine-Tryptophan-Ketoglutarate Solution VS University of Wisconsin Solution for Deceased Donor Liver Transplantation: Analysis of UNOS Database, P-281, ILTS Conference, New York, NY, (July 9, 2009) |
|||
27. Walcher, F. et al, The impact of liver preservation in HTK and UW solution on microcirculation after liver transplantation, Transplant International, (1992) 5 [Suppl 1]: S 340-S 342 |
|||
28. Welling, T. H. et al, Biliary Complications Following Liver Transplantation in the Model for End-Stage Liver Disease Era: Effect of Donor, Recipient, and Technical Factors, Liver Transplantation 14:73-80, 2008 |
|||
==External links== |
==External links== |
||
Revision as of 18:35, 2 March 2012
Histidine-tryptophan-ketoglutarate, or Custodiol HTK solution is a high-flow, low-potassium preservation solution used for organ transplantation.
HTK solution is intended for perfusion and flushing of donor liver kidney, heart, lung and pancreas prior to removal from the donor and for preserving these organs during hypothermic storage and transport to the recipient. HTK solution is based on the principle of inactivating organ function by withdrawal of extracellular sodium and calcium, together with intensive buffering of the extracellular space by means of histidine/histidine hydrochloride, so as to prolong the period during which the organs will tolerate interruption of oxygenated blood. The composition of HTK is similar to that of extracellular fluid. All of the components of HTK occur naturally in the body.
| Component | HTK |
|---|---|
| Sodium (mmol/L) | 15 |
| Potassium (mmol/L) | 10 |
| Magnesium (mmol/L) | 4 |
| Calcium (mmol/L) | 0.015 |
| Ketoglutarate/glutamic acid (mmol/L) | 1 |
| Histidine (mmol/L) | 198 |
| Mannitol (mmol/L) | 30 |
| Tryptophan (mmol/L) | 2 |
| Osmolarity (mOsm/L) | 310 |
Custodiol HTK is the registered trademark of Dr. Franz Köhler (Chemie GmbH, Germany).
References
 | This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. (April 2009) |
1. Abou Abbass, A. et al, Biliary Complications After Orthotopic Liver Transplantation From Donors After Cardiac Death: Broad Spectrum of Disease, Transplantation Proceedings, Vol. 42, 3392-3398, Dec. 2010
2. Agarwal, A. et al, Comparison of Histidine-Tryptophan Ketoglutarate and University of Wisconsin Solutions as Primary Preservation in Renal Allografts Undergoing Pulsatile Perfusion, Transplantation Proceedings, 37, 2016-2019 (2005)
3. Agarwal, A. et al, Organ Preservation With Histidine-Tryptophan Ketoglutarate Solution in Clinical Pancreas Transplantation: An Update of the Indiana University Experience, Transplantation Proceedings, 40, 498-501 (2008)
4. Anaya-Prado, R. et al, Scientific basis of organ preservation, Current Opinion in Organ Transplantation, 2008 13:129-134
5. Becker, T. et al, Pancreas Transplantation with Histidine-Tryptophan-Ketoglutarate (HTK) Solution and University of Wisconsin (UW) Solution: Is There A Difference?, Journal of the Pancreas, Vol. 8, No. 3, May 2007
6. Botta, L., et al, Cardiac transplantation with a donor hear rescued from deep hypothermia, The Journal of Heart and Lung Transplantation, Vol. 30, No. 10, October 2011, 1203-1204
7.Chok, K.S.H. et al, Bile Duct Anastomotic Stricture After Adult-to-Adult Right Lobe Living Donor Liver Transplantation, Liver Transplantation, 17:47-52, 2011
8. Cui, D.X. et al, Effect of Different Bile Duct Flush Solutions on Biliary Tract Preservation Injury of Donated Livers for Transplantation, Transplantation Proceedings , Vol 42. 1576-1581, June 2010
9. Cywinski, J. B. et al, Association Between Donor-Recipient Serum Sodium Differences and Orthotopic Liver Transplant Graft Function, Liver Transplantation 14:59-65, 2008
10. De Vera, M.E. et al, Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center, American Journal of Transplantation 2009, 9: 773-781
11. Feng, X.-N. et al, Current status and perspective of liver preservation solutions, Hepatobility Pancreat Dis Int, Vol. 5, No. 4, November 15, 2006
12. Fridell, JA, et al, Clinical experience with histidine-tryptophan-ketoglutarate solution in abdominal organ preservation: a review of recent literature, Clinical Transplantation, 2008 DOI 10.1111/j.1399-0012
13. Fridell, J.A. et al, Histidine-Tryptophan-Ketoglutarate for Pancreas Allograft Preservation: The Indiana University Experience, American Journal of Transplantation, 2010, 10: 1-6
14. Gkouziouta, A. et al, Heart Transplantation in a Low-Organ-Donation Environment: A Single Center Experience, Transplantation Proceedings, 41, 4289-4293 (2009)
15. Lee, S. et al, Superior myocardial preservation with HTK solution over Celsior in rat hearts with prolonged cold ischemia, Surgery (2010), 148:463-73
16. Lynch, R. J. et al, Comparison of Outcomes with HTK and UW Solutions in Renal Transplantation, American Journal of Transplantation, 2008, 8: 1958
17. Maheshwari, A. et al, Biliary Complications and Outcomes of Liver Transplantation from Donors after Cardiac Death, Liver Transplantation, 13:1645-1653, 2007
18. Mangus, R., et al, A Comparison of Histidine-Tryptophan-Ketoglutarate and University of Wisconsin Solutions in Bowel Transplantation, Abstract, Transplant International, Vol. 20, Supplement 2, September 2007
19. Mangus, R. S. et al, Comparison of Histidine-Tryptophan-Ketoglutarate Solution and University of Wisconsin Solution in Extended Criteria Liver Donors, Liver Transplantation, 14: 365-373, 2008
20. Mangus, R., et al, Comparison of Histidine-Tryptophan-Ketoglutarate Solution and University of Wisconsin Solution in Intestinal and Multivisceral Transplantation, Transplantation, Vol. 86, Number 2, July 27, 2008
21. O’Callaghan, J.M. et al, Preservation Solutions for Static Cold Storage of Kidney Allografts: A Systematic Review and Meta-Analysis, American Journal of Transplantation, October 2011.
22. Schneeburger, S. et al, A prospective randomized multicenter trial comparing histidine-tryptophane-ketoglutarate versus University of Wisconsin perfusion solution in clinical pancreas transplantation, Transplant International, 2008, 9:1-8
23. Schneeberger, S. et al, Atypical Acute Rejection After Hand Transplantation, American Journal of Transplantation 2008, 8: 688-696
24. Simoes, E.A., et al, Comparing the Performance of Rat Lungs Preserved for 6 or 12 Hours After Perfusion With Low Potassium Dextran or Histidine-Tryptophan-Ketoglutarate, Transplantation Proceedings, 43, 1520-1524 (2011)
25. Sucher, R. et al, Investigation of the Role of Ischemia and Reperfusion in Limb Transplantation, American Transplant Congress 09, Boston, MA, Abstract 1062, (May 31, 2009)
26. Tellioglu, G. et al, Histidine-Tryptophan-Ketoglutarate Solution VS University of Wisconsin Solution for Deceased Donor Liver Transplantation: Analysis of UNOS Database, P-281, ILTS Conference, New York, NY, (July 9, 2009)
27. Walcher, F. et al, The impact of liver preservation in HTK and UW solution on microcirculation after liver transplantation, Transplant International, (1992) 5 [Suppl 1]: S 340-S 342
28. Welling, T. H. et al, Biliary Complications Following Liver Transplantation in the Model for End-Stage Liver Disease Era: Effect of Donor, Recipient, and Technical Factors, Liver Transplantation 14:73-80, 2008