Illinois Route 169 is an east–west state road in far southern Illinois. It runs from Illinois Route 37 north of Grand Chain east to U.S. Route 45 east of Boaz. This is a distance of 9.04 miles (14.55 km).
Illinois 169 is the southernmost main arterial route between Illinois 37 and U.S. 45. It is also the southernmost east–west state route in Illinois. Illinois 169 is a two-lane surface road for its entire length.
SBI Route 169 originally ran from Shelbyville to Dalton City on what is now Illinois Route 128. It was moved to its current route in 1949.