Infected cell protein 47
Infected cell protein 47 also ICP-47 or ICP47 is a protein secreted by the viruses such as Herpes simplex virus and Cytomegalovirus that allows them to evade the human immune system's CD8 T-cell response.[1]
Method of action
It works by inhibiting transfer of viral particles to the human TAP proteins and thus entry of viral peptides into the endoplasmic reticulum, which is supposed to bind them to MHC class I molecules[1] for extracellular T-cell recognition so the viral component will trigger immune defense response as a foreign entity.[2] However human or some animal TAP proteins differs in mice making rodents far less susceptible than humans to HSV.
Structure
- triple helix[3]
References
- ^ a b http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.6406
- ^ Berger, C; Xuereb, S; Johnson, DC; Watanabe, KS; Kiem, HP; Greenberg, PD; Riddell, SR (2000). "Expression of herpes simplex virus ICP47 and human cytomegalovirus US11 prevents recognition of transgene products by CD8(+) cytotoxic T lymphocytes". J. Virol. 74: 4465–73. doi:10.1128/jvi.74.10.4465-4473.2000. PMC 111967. PMID 10775582.
- ^ http://www.ebi.ac.uk/interpro/entry/IPR008026
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