The club was founded in 1957 as Hapoel Ramat HaSharon, the club was promoted to Liga Artzit (then the second division) in 1984. In the 1984–85 season they narrowly missed out on promotion to Liga Leumit (then the top division), after losing 1–0 to Hapoel Jerusalem on the final day of the season; had they won, they would have been promoted in Jerusalem's place. The following season they were relegated to Liga Alef, and two seasons later to Liga Bet. During the 1990s the club was renamed after former player Nir Itzhaki.
In 1996 the club returned to Liga Alef. In 1999–2000 they finished second in their division. Due to Beitar Tel Aviv and Shimshon Tel Aviv merging, the club was promoted to Liga Artzit (now the third tier) to fill the vacancy. In 2002–03 they narrowly avoided relegation, finishing one place above the relegation zone. The following season they won the league to earn promotion back to the second division. In the same season they also won the Liga Artzit Toto Cup.
In the 2009–10 season the club made one of its biggest achievements in the club's history when the team reached the semi final of the Israel State Cup.
In the 2010–11 season the club won the Toto Cup Leumit and got promoted to the Israeli Premier League for the first time in the history of the club after they finished as champions of Liga Leumit. In June 2013, the club changed its name from Ironi Nir Ramat HaSharon to Hapoel Nir Ramat HaSharon and resulted in a new logo.
In the 2012–13 season, the club achieved its best placing to date, when they finished sixth in the Israeli Premier League. However, in the following season, the club finished second bottom and relegated to Liga Leumit.