He was born in Tours in 1686, and by the age of 13, had already made his first clock. In 1699, he moved to Paris for further training. He became maitre horloger in 1713 and later juré of his guild. Further appointments followed, including the Directorship of the Société des Arts, but the pinnacle of his achievement was being appointed clockmaker (Horloger Ordinaire du Roi) to King Louis XV in 1739. He carried on his business from premises in the Rue du Harlay until his death in 1759.
His son Pierre Le Roy (1717–1785), a brilliant clock-maker in his own right, carried on the business until the early 1780s. Another son, Julien-David Le Roy (1724–1803), was a neo-classical architect and archaeologist, author of the Ruins of the Most Beautiful Monuments of Greece.