KASH domains

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Nuclear envelope localisation domain
Symbol KASH
Pfam PF10541
InterPro IPR012315

KASH domains are conserved C-terminal protein regions less than ~30 amino acids. KASH is an acronym for Klarsicht, ANC-1, Syne Homology. KASH domains always follow a transmembrane domain. Most proteins containing KASH domains are thought to be involved in the positioning of the nucleus in the cell.[1] KASH domains interact with proteins containing SUN domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope, and may transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton and enable mechanosensory roles in cells.[2][3] KASH proteins are thought to largely localize to the outer nuclear membrane, although there are reports of inner nuclear membrane localization of some KASH protein isoforms.[4]

Examples of KASH proteins[edit]

Caenorhabditis elegans

  • UNC-83
  • ANC-1
  • ZYG-12


  • Nesprins-1, 2, 3 and 4 (also called Synes, Mynes, Nuance, Enaptin)

Drosophila melanogaster

  • Klarsicht
  • MSP-300


  1. ^ Wilhelmsen, Kevin; Ketema, Mirjam; Truong, Hoa; Sonnenberg, Arnoud (2006-12-15). "KASH-domain proteins in nuclear migration, anchorage and other processes". Journal of Cell Science. 119 (Pt 24): 5021–5029. doi:10.1242/jcs.03295. ISSN 0021-9533. PMID 17158909. 
  2. ^ Uzer et al. (2015) "Cell mechanosensitivity to extremely low magnitude signals is enabled by a LINCed nucleus" Stem Cells,doi: 10.1002/stem.2004 PMID 25787126
  3. ^ Wilhelmsen, Kevin; Litjens, Sandy H. M.; Kuikman, Ingrid; Tshimbalanga, Ntambua; Janssen, Hans; van den Bout, Iman; Raymond, Karine; Sonnenberg, Arnoud (2005-12-05). "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin". The Journal of Cell Biology. 171 (5): 799–810. doi:10.1083/jcb.200506083. ISSN 0021-9525. PMC 2171291Freely accessible. PMID 16330710. 
  4. ^ Starr DA, Fischer JA (Nov 2005). "KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins". BioEssays. 27 (11): 1136–46. doi:10.1002/bies.20312. PMID 16237665. 

External links[edit]