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LES may refer to:

Space flight[edit]

Biology and medicine[edit]

Other uses[edit]


  • The Lower East Side neighborhood of Manhattan, New York City
  • Les, Catalonia, Spain
  • Leş, a village in Nojorid Commune, Bihor County, Romania
  • Les, the Hungarian name for Leșu Commune, Bistriţa-Năsăud County, Romania