The line is part of the government-owned railway network (DB Netz) and is currently (2012) served by passenger trains (GTW 2/6) operated by the HLB Hessenbahn GmbH, a subsidiary of Hessische Landesbahn, on behalf of the Rhein-Main-Verkehrsverbund (Rhine-Main Transport Association, RMV).
In the 2003/2004 timetable, which commenced on 14 December 2003, services on weekends and holidays was reordered. In addition, the Nidda–Glauburg–Büdingen–Gelnhausen section is served every morning and evening by bus line 374. Until the 2009/2010 timetable, this route was still called line 610 and served the whole line from Gelnhausen to Gießen.
Planning on the line began in 1862 and it was built and operated by the Upper Hessian Railway Company (Oberhessische Eisenbahn-Gesellschaft) and opened in several sections:
An extension to Partenstein on the Bavarian Ludwig's Western Railway (Ludwigs-West-Bahn) did not come about. However, the line became important from 1888 with the integration of some branch lines in the Vogelsberg and Wetterau.
The Upper Hessian Railway Company was nationalised in 1876 and its operations were taken over by the Grand Duchy of Hesse State Railways (Großherzoglich Hessische Staatseisenbahnen).
- Adolf Kaiser (2010). 140 Jahre Eisenbahn in Oberhessen : Ein Jahrhundert verändert die Region. (in German). Büdingen, Hess: Geschichtswerkstatt Büdingen. ISBN 978-3-939454-59-5.
- Wilhelm Lepper. "Unterwegs auf unseren Straßen : Verkehrslandschaft Wetterau". Die Wetterau (in German). Friedberg 1983: Kreissparkasse Friedberg. p. 203. ISBN 3-87076-038-9.
- Jürgen Röhrig Schriftenreihe. Oberhessischen Eisenbahnen (in German).
- Jürgen Röhrig (11 July 2009, archivied on 6 January 2010). "Rübenwagen sind längst Geschichte". Gießener Anzeiger (in German). Retrieved 20 February 2012.