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Life Itself may refer to:
- Life Itself (2014 film), a documentary, film adaptation of film critic Roger Ebert's memoir
- Life Itself (2018 film), an English-language romance drama film
- "Life Itself" (George Harrison song), a song by George Harrison from Somewhere in England
- "Life Itself", a song by Glass Animals from How to Be a Human Being
- "Life Itself", a song by Bruce Springsteen from Working on a Dream
- Life Itself: A Memoir, a 2011 memoir by film critic Roger Ebert
- Life Itself: Its Origin and Nature, a 1981 book by Francis Crick
- Life Itself: A Comprehensive Inquiry Into the Nature, Origin, and Fabrication of Life, a 1991 book by Robert Rosen
| disambiguation page lists articles associated with the title Life Itself.
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