List of highways numbered 280
Route 280, or Highway 280, may refer to:
Canada
Japan
United States
- Interstate 280
- U.S. Route 280
- Arizona State Route 280 (former)
- Arkansas Highway 280
- Florida State Road 280 (former)
- Georgia State Route 280
- Kentucky Route 280
- Maryland Route 280 (former)
- Minnesota State Highway 280
- Montana Secondary Highway 280
- New York State Route 280
- North Carolina Highway 280
- Pennsylvania Route 280 (former)
- South Carolina 280
- Tennessee State Route 280
- Texas State Highway Spur 280
- Farm to Market Road 280 (Texas)
- Utah State Route 280