- Preston Sherburne (born 2004), American Football Player
- Preston Bassett (1892–1992), American inventor and engineer
- Preston Blair (1908–1995), American animator
- Preston J. Bradshaw (1884–1952), American architect
- Preston Brooks (1819–1857), American politician
- Preston Brown (disambiguation), multiple people
- Preston M. Burch (1884–1978), American racehorse trainer
- Preston Burpo (born 1972), American soccer player
- Preston Bynum (born 1939), American politician and businessman
- Preston Campbell (born 1977), Australian rugby league footballer
- Preston W. Campbell (1874–1954), American lawyer
- Preston Carpenter (1934–2011), American football player
- Preston Carrington (born 1949), American athlete
- Preston Cloud (1912–1991), American paleontologist and geologist
- Preston Scott Cohen, American architect
- Preston Corderman (1904–1998), American army officer
- Preston Covey, American philosopher
- Preston Daniels, American politician and first African-American mayor of Des Moines, Iowa
- Preston Davie (1881–1967), American lawyer and colonel
- Preston Davis (1907–1990), American politician
- Preston Davis (American football) (born 1962), American football player
- Preston Delano (c.1886–1961), American businessman
- Preston Dennard (born 1955), American football player
- Preston Dickinson (1889–1930), American artist
- Preston Doerflinger (born 1973), American businessman and politician
- Preston Edwards (born 1989), English footballer
- Preston Elliott (1875–1939), Canadian farmer and politician
- Preston Epps (born 1931), American musician
- Preston Estep, American biologist
- Preston Fleet (1934–1995), American businessman
- Preston Foster (1900–1970), American actor
- Preston Glass (born 1960}, American songwriter and producer
- Preston Gothard (born 1962), American football player
- Preston Griffall (born 1984), American luger
- Preston Gómez (1923–2009), Cuban-born baseball player
- Preston Hanna (born 1954), American baseball player
- Preston Hanson (1921–2008), American actor
- Preston Haskell (born 1938), American businessman
- Preston Henn (born 1931), American entrepreneur
- Preston Heyman, British drummer
- Preston Holder (1907–1980), American archaeologist and photographer
- Preston Jackson (1902–1983), American musician
- Preston Jones (disambiguation), multiple people
- Preston Keat (born 1966), American political scientist
- Preston King (disambiguation) (1806–1865), American politician
- Preston Knowles (born 1989), American basketball player
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- Preston Lacy (born 1969), American actor
- Preston Lea (1841–1916), American businessman and politician
- Preston Leslie (1819–1907), American politician
- Preston Lockwood (1912–1996), English actor
- Preston Love (1921–2004), American jazz musician
- Preston McAfee (born 1956), American economist
- Preston McGann, American football player
- Preston Manning (born 1942), Canadian politician
- Preston Martin (1923–2007), American banker
- Preston D. Miller, periodontist
- Preston Mitchell, American football coach
- Preston Mommsen (born 1987), South African born Scottish cricketer
- Preston Nash, American musician
- Preston Nibley (1884–1966), American religious leader
- Preston Nichols (born 1946), American author
- Preston Ware Orem (1865–1938), American composer, pianist and writer
- Preston Parker (born 1987), American football player
- Preston Parks, American politician
- Preston Parsons (born 1979), American football player
- Preston Pearson (born 1945), American football player
- Preston E. Peden (1914–1985), American politician
- Preston B. Plumb (1837–1891), American politician
- Preston Powers (1842–1904), American sculptor, painter and teacher
- Preston Quick (born 1978), American squash player
- Preston Reed (born 1955), American guitarist
- Preston Richards(born 1881), American lawyer
- Preston Ridd (born 1953), New Zealand darts player
- Preston Ridlehuber (born 1943), American football player
- Preston Ritter (born 1949), musician
- Preston Shumpert (born 1979), American-Turkish basketball player
- Preston Singletary (born 1963), American glass artist
- Preston Smith (disambiguation), multiple people
- Preston Strother (born 1999), American actor
- Preston Sturges (1898–1959), American writer and director
- Preston Stutzman, American film producer and actor
- Preston Robert Tisch (1926–2005), American businessman
- Preston Tucker (1903–1956), American automobile designer and entrepreneur
- Preston Ward (born 1927), American baseball player
- Preston Ware (1821–1890), American chess player
- Preston Washington (1948–2003), American religious leader
- Preston Watson (1880–1915), Scottish aviator
- Preston A. Whitmore II, American screenwriter, producer and director
- Preston Wilson (born 1974), American baseball player
- Preston Young (born 1954), Canadian football player
- Preston Zimmerman (born 1988), American soccer player
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