MBOAT

MBOAT_2
MBOAT_2
Identifiers
Symbol	MBOAT_2
Pfam	PF13813
Pfam clan	CL0517
InterPro	IPR004299
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

MBOAT
MBOAT
Identifiers
Symbol	MBOAT
Pfam	PF03062
Pfam clan	CL0517
InterPro	IPR004299
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

The MBOAT (membrane bound O-acyl transferase) family of membrane proteins is a family of various acyltransferase enzymes. All family members contain multiple transmembrane domains and most carry two conserved residues which might be active-site residues, a conserved histidine (His) embedded in a hydrophobic stretch of residues and an asparagine (Asn) or histidine within a more hydrophilic region some 30-50 residues upstream.^[1]

MBOAT enzymes catalyze the transfer of an acyl group from acyl-coenzyme to one of several different substrates. The family is found from bacteria to eukaryotes, and the active region lies outside the membrane.^[2]

The family may be grouped into four categories, according to function:

Subgroup 1: enzymes involved in neutral lipid biosynthesis;
Subgroup 2: enzymes involved in protein/peptide acylation;
Subgroup 3: enzymes involved in phospholipid re-modelling.^[3]

References

^ Hofmann K (March 2000). "A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling". Trends Biochem. Sci. 25 (3): 111–2. doi:10.1016/s0968-0004(99)01539-x. PMID 10694878.
^ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. doi:10.1007/s11515-011-1149-z.
^ Wang P, Wang Z, Dou Y, Zhang X, Wang M, Tian X (2013). "Genome-wide identification and analysis of membrane-bound O-acyltransferase (MBOAT) gene family in plants". Planta. 238 (5): 907–22. doi:10.1007/s00425-013-1939-4. PMID 23928653.

This article incorporates text from the public domain Pfam and InterPro: IPR004299

[pmid10694878-1] Hofmann K (March 2000). "A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling". Trends Biochem. Sci. 25 (3): 111–2. doi:10.1016/s0968-0004(99)01539-x. PMID 10694878.

[pmidDOI_10.1007/s11515-011-1149-z-2] Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. doi:10.1007/s11515-011-1149-z.

[pmid23928653-3] Wang P, Wang Z, Dou Y, Zhang X, Wang M, Tian X (2013). "Genome-wide identification and analysis of membrane-bound O-acyltransferase (MBOAT) gene family in plants". Planta. 238 (5): 907–22. doi:10.1007/s00425-013-1939-4. PMID 23928653.

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[2]

[3]