MED29
| Med29 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Med29 | ||||||||
| Pfam | PF11568 | ||||||||
| InterPro | IPR021018 | ||||||||
| |||||||||
Mediator of RNA polymerase II transcription subunit 29 is a transcription suppressor that in humans is encoded by the MED29 gene.[1] It represents subunit MED29 of the Mediator complex.
MED29, along with Med11 and MED28 in mammals, is part of the core head-region of the Mediator complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein (IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.[2]
References
- ^ Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, et al. (2004). "IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor". Biochem Biophys Res Commun. 325 (4): 1330–8. doi:10.1016/j.bbrc.2004.10.159. PMID 15555573.
- ^ Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW (May 2005). "The mammalian Mediator complex and its role in transcriptional regulation". Trends Biochem. Sci. 30 (5): 250–5. doi:10.1016/j.tibs.2005.03.002. PMID 15896743.