KAT6A
Template:PBB MYST histone acetyltransferase (monocytic leukemia) 3, also known as MYST3, is an enzyme that, in humans, is encoded by the MYST3 gene.[1][2]
Function
MYST3 contains two nuclear localization domains, a C2HC3 zinc finger and an acetyltransferase domain. This structure suggests that MYST3 functions as a chromatin-bound acetyltransferase.[2] MYST3 is important for proper development of hematopoietic stem cells.[3]
References
- ^ "Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3".
- ^ a b Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (September 1996). "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33–41. doi:10.1038/ng0996-33. PMID 8782817.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yang XJ, Ullah M (August 2007). "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells". Oncogene. 26 (37): 5408–19. doi:10.1038/sj.onc.1210609. PMID 17694082.
Further reading
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