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Maytansinoid

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A maytansinoid is a chemical derivative of maytansine.[1]

Some are being investigated as the cytotoxic component of antibody-drug conjugates.[1] Anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function. The maytaninoid emtansine (DM1), for example, binds at the ends of microtubules and thereby suppress their dynamic instability[2]

Examples:

See also

References

  1. ^ a b Chari, RV; Martell, BA; Gross, JL; et al. (January 1992). "Immunoconjugates containing novel maytansinoids: promising anticancer drugs" (PDF). Cancer Res. 52: 127–31. PMID 1727373. {{cite journal}}: Explicit use of et al. in: |last4= (help)
  2. ^ Lopus, M; Oroudjev, E; Wilson, L; Wilhelm, S; Widdison, W; Chari, R; Jordan, MA (2010). "Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules". Mol Cancer Ther. 9: 2689–99. doi:10.1158/1535-7163.MCT-10-0644. PMC 2954514. PMID 20937594.
  3. ^ Yu, TW; Bai, L; Clade, D; et al. (June 2002). "The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnemapretiosum". Proc. Natl. Acad. Sci. U.S.A. 99: 7968–73. doi:10.1073/pnas.092697199. PMC 123004. PMID 12060743. {{cite journal}}: Explicit use of et al. in: |last4= (help)


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