Messenger RNP
Messenger RNP (messenger ribonucleoprotein) is mRNA with bound proteins. mRNA does not exist "naked" in vivo but is always bound by various proteins while being synthesized, spliced, exported, and translated in the cytoplasm.[1][2]
When mRNA is being synthesized by RNA polymerase, this nascent mRNA is already bound by RNA 5′ end 7-methyl-guanosine capping enzymes. Later, mRNA is bound by exon and intron definition complexes, and splicing snRNPs. The spliced mRNA is bound by another set of proteins which help in export from the nucleus to the cytoplasm. In vertebrates exon-exon junction are marked by exon junction complexes which in the cytosol can trigger nonsense mediated decay if the exon-exon junction is more than 50-55 nt downstream of the stop codon.[3]
See also
References
- ^ Hieronymus, Haley; Pamela A. Silver (2004-12-01). "A systems view of mRNP biology". Genes & Development. 18 (23): 2845–2860. doi:10.1101/gad.1256904. ISSN 0890-9369. PMID 15574591. Retrieved 2013-07-24.
- ^ Bergkessel, Megan; Gwendolyn M. Wilmes; Christine Guthrie (2009-02-20). "SnapShot: Formation of mRNPs". Cell. 136 (4): 794-794.e1. doi:10.1016/j.cell.2009.01.047. ISSN 0092-8674. PMID 19239896. Retrieved 2013-07-24.
- ^ Lykke-Andersen, Søren; Jensen, Torben Heick (2015-09-23). "Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes". Nature Reviews Molecular Cell Biology. 16 (11): 665–677. doi:10.1038/nrm4063. ISSN 1471-0080.
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