Microextraction by packed sorbent

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Microextraction by packed sorbent (MEPS) is a solid phase extraction method that uses a packed sorbent material in a liquid handling syringe.[1] [2]

Construction and operation[edit]

The SPE sorbent materials are packed in the cartridge that is integrated into a microliter syringe. The syringe can be any type of manual or autosampler syringe used in gas chromatography or liquid chromatography.[3] MEPS is suitable to reversed phase, normal phase, mixed mode or ion exchange chemistries. Instead of the milliliter volumes of solvent required to elute a standard SPE cartridge or disk, MEPS cartridges are capable of giving a total elution volume of a few microliters.[citation needed] This elution volume is such that it can easily be injected directly into a gas chromatograph or liquid chromatograph without further sample concentration. Full automation of sample preparation and analysis of the extracted sample can easily be achieved using a conventional autosampler. MEPS uses 100 times less sample and solvent than conventional SPE techniques.[citation needed]


  1. ^ Abdel-Rehim, Mohamed (2011). "Microextraction by packed sorbent (MEPS): A tutorial". Analytica Chimica Acta 701 (2): 119–128. doi:10.1016/j.aca.2011.05.037. ISSN 0003-2670. 
  2. ^ M. Abdel-Rehim, AstraZeneca Application “Syringe for solid phase microextraction”, Current Patents Gazette, week 0310, WO 03019149, p. 77, (2003).
  3. ^ Abdel-Rehim, Mohamed (2004). "New trend in sample preparation: on-line microextraction in packed syringe for liquid and gas chromatography applications". Journal of Chromatography B 801 (2): 317–321. doi:10.1016/j.jchromb.2003.11.042. ISSN 1570-0232.