The SPE sorbent materials are packed in the cartridge that is integrated into a microliter syringe. The syringe can be any type of manual or autosampler syringe used in gas chromatography or liquid chromatography. MEPS is suitable to reversed phase, normal phase, mixed mode or ion exchange chemistries. Instead of the milliliter volumes of solvent required to elute a standard SPE cartridge or disk, MEPS cartridges are capable of giving a total elution volume of a few microliters. This elution volume is such that it can easily be injected directly into a gas chromatograph or liquid chromatograph without further sample concentration. Full automation of sample preparation and analysis of the extracted sample can easily be achieved using a conventional autosampler. MEPS uses 100 times less sample and solvent than conventional SPE techniques.
^M. Abdel-Rehim, AstraZeneca Application “Syringe for solid phase microextraction”, Current Patents Gazette, week 0310, WO 03019149, p. 77, (2003).
^Abdel-Rehim, Mohamed (2004). "New trend in sample preparation: on-line microextraction in packed syringe for liquid and gas chromatography applications". Journal of Chromatography B801 (2): 317–321. doi:10.1016/j.jchromb.2003.11.042. ISSN1570-0232.