N-Phenylnaphthalen-1-amine

N-Phenylnaphthalen-1-amine
Names
	Preferred IUPAC name N-Phenylnaphthalen-1-amine
	Other names Anilinonaphthalene; α-Naphthylphenylamine;
Identifiers
CAS Number	90-30-2 ;
3D model (JSmol)	Interactive image;
Abbreviations	PANa
ChemSpider	6746;
ECHA InfoCard	100.001.803
PubChem CID	7013;
UNII	5I112077IN ;
CompTox Dashboard (EPA)	DTXSID2025892 ;
	InChI InChI=1S/C16H13N/c1-2-9-14(10-3-1)17-16-12-6-8-13-7-4-5-11-15(13)16/h1-12,17H Key: XQVWYOYUZDUNRW-UHFFFAOYSA-N; InChI=1/C16H13N/c1-2-9-14(10-3-1)17-16-12-6-8-13-7-4-5-11-15(13)16/h1-12,17H Key: XQVWYOYUZDUNRW-UHFFFAOYAN;
	SMILES c3c(Nc1ccccc1)c2ccccc2cc3;
Properties
Chemical formula	C16H13N
Molar mass	219.287 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

N-Phenylnaphthalen-1-amine (NPN) is an aromatic amine with the chemical formula C
₁₆H
₁₂NH.

This molecule is notable for its binding affinity in mouse major urinary protein (MUP). This ligand has the greatest binding affinity of all MUP binding ligand discovered, including 2-sec-butyl-4,5-dihydrothiazole (SBT), 6-hydroxy-6-methyl-3-heptanone (HMH), and 3-isobutyl-2-methoxypyrazine (IBMP). NPN binds 28 times tighter than SBT. It also makes 38 nonpolar contacts to MUP, whereas IBMP only makes 15 contacts which are the next most nonpolar contacts.^[1] There is a slight difference in the binding affinities and forms for NPN bound in wild-type MUP and the Y120F MUP mutant. In wild-type MUP there is just enough room for the amine group of NPN to makes a water mediated hydrogen bond to Tyr120, whereas in Y120F MUP mutant, there is a slight shift and the amine group makes a direct hydrogen bond to Tyr120. Much is still unknown about the entropic and enthalpic effects of the MUP binding site.^[2]

References

^ Pertinhez TA, Ferrari E, Casali E, Patel JA, Spisni A, Smith LJ (1 December 2009). "The binding cavity of mouse major urinary protein is optimised for a variety of ligand binding modes". Biochemical and Biophysical Research Communications. 390 (4): 1266–1271. doi:10.1016/j.bbrc.2009.10.133. PMID 19878650.
^ Homans, SW (July 2007). "Water, water everywhere--except where it matters?". Drug Discovery Today. 12 (13–14): 534–9. doi:10.1016/j.drudis.2007.05.004. PMID 17631247.

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[1] Pertinhez TA, Ferrari E, Casali E, Patel JA, Spisni A, Smith LJ (1 December 2009). "The binding cavity of mouse major urinary protein is optimised for a variety of ligand binding modes". Biochemical and Biophysical Research Communications. 390 (4): 1266–1271. doi:10.1016/j.bbrc.2009.10.133. PMID 19878650.

[2] Homans, SW (July 2007). "Water, water everywhere--except where it matters?". Drug Discovery Today. 12 (13–14): 534–9. doi:10.1016/j.drudis.2007.05.004. PMID 17631247.

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