Naa80

N-acetyltransferase 6 (GCN5-related) is a protein that in humans is encoded by the NAT6 gene.

Function

This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl-CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3, and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011].

Further reading

• Shuttleworth, T. L.; Wilson, M. D.; Wicklow, B. A.; Wilkins, J. A.; Triggs-Raine, B. L. (2002). "Characterization of the Murine Hyaluronidase Gene Region Reveals Complex Organization and Cotranscription of Hyal1 with Downstream Genes, Fus2 and Hyal3". Journal of Biological Chemistry. 277 (25): 23008–23018. doi:10.1074/jbc.M108991200. PMID 11929860.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Muzny, D. M.; Scherer, S. E.; Kaul, R.; Wang, J.; Yu, J.; Sudbrak, R.; Buhay, C. J.; Chen, R.; Cree, A.; Ding, Y.; Dugan-Rocha, S.; Gill, R.; Gunaratne, P.; Harris, R. A.; Hawes, A. C.; Hernandez, J.; Hodgson, A. V.; Hume, J.; Jackson, A.; Khan, Z. M.; Kovar-Smith, C.; Lewis, L. R.; Lozado, R. J.; Metzker, M. L.; Milosavljevic, A.; Miner, G. R.; Morgan, M. B.; Nazareth, L. V.; Scott, G.; Sodergren, E. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–1198. doi:10.1038/nature04728. PMID 16641997.
• Zegerman, P.; Bannister, A. J.; Kouzarides, T. (2000). "The putative tumour suppressor Fus-2 is an N-acetyltransferase". Oncogene. 19 (1): 161–163. doi:10.1038/sj.onc.1203234. PMID 10644992.
• Yi Lo, P. H.; Chung Leung, A. C.; Xiong, W.; Law, S.; Duh, F. M.; Lerman, M. I.; Stanbridge, E. J.; Lung, M. L. (2006). "Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas". Cancer Letters. 234 (2): 184–192. doi:10.1016/j.canlet.2005.03.036. PMID 15885884.
• Lerman, M. I.; Minna, J. D. (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–6133. PMID 11085536.
• Duh, F. M.; Fivash, M.; Moody, M.; Li Lung, M.; Guo, X.; Stanbridge, E.; Dean, M.; Voevoda, M.; Hu, L. F.; Kashuba, V.; Zabarovsky, E. R.; Qian, C. N.; Godbole, S.; Tean Teh, B.; Lerman, M. I. (2004). "Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: Prevalence in Asian populations and analysis of association with nasopharyngeal cancer". Molecular and Cellular Probes. 18 (1): 39–44. doi:10.1016/j.mcp.2003.09.002. PMID 15036368.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.