Jump to content

NRON

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Dcirovic (talk | contribs) at 01:02, 4 June 2016 (clean up using AWB). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

ncRNA Repressor of NFAT (nuclear factor of activated T cells)
Identifiers
SymbolNRON
RfamRF00636
Other data
RNA typeGene
Domain(s)Eukaryota
SOSO:0001263
PDB structuresPDBe

NRON also known as ncRNA repressor of the nuclear factor of activated T cells is a non-coding RNA involved in repressing NFAT.[1] The function of this ncRNA was identified by a large-scale screen of 512 non-coding RNAs discovered in earlier EST sequencing projects.[2][3]

Each of the RNAs that were conserved between human and mouse were knocked down using shRNAs. The resulting cell-lines were screened for changes in activity of NFAT.

References

  1. ^ Willingham AT; Orth AP; Batalov S; et al. (September 2005). "A strategy for probing the function of noncoding RNAs finds a repressor of NFAT". Science. 309 (5740): 1570–3. doi:10.1126/science.1115901. PMID 16141075. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  2. ^ Okazaki Y; Furuno M; Kasukawa T; et al. (December 2002). "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs". Nature. 420 (6915): 563–73. doi:10.1038/nature01266. PMID 12466851. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  3. ^ Numata K; Kanai A; Saito R; Kondo S; Adachi J; Wilming LG; Hume DA; Hayashizaki Y; Tomita M; RIKEN GER Group; GSL Members (2003). "Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection". Genome Res. 13 (6B): 1301–6. doi:10.1101/gr.1011603. PMC 403720. PMID 12819127.