Kỳ Duyên was born in Saigon, South Vietnam and was almost ten years old during the "fall of Saigon" on April 30, 1975, when her family left for the United States. Her father, Nguyễn Cao Kỳ, was a former South Vietnamese Prime Minister, Vice President, and Air-Force General.
Kỳ Duyên currently works as a star Master of Ceremonies for Thuy Nga's Paris By Night production alongside MC Nguyen Ngoc Ngan (she has been working for Thuy Nga since the early 1990s). Kỳ Duyên also hosts a television shopping show on Vietface TV, VietToday Channel and has an e-commerce website www.kyduyenhouse.com where she distributes her products to retail customers as well as wholesalers. She is a sought-after spokesperson for many brands and products all over the world, especially in the US and Vietnam. She currently resides in Orange County, California.
Her first marriage was to Li Nguyen, a surgeon, then Trịnh Hội, a lawyer (whom she divorced in 2008). For the past 3 years, she has been publicly linked to Duy Han, a financial analyst and writer. She currently resides in Costa Mesa, California with her two daughters from her first marriage to Li Nguyen.