Kỳ Duyên was born in Saigon, South Vietnam and was almost ten years old during the "fall of Saigon" on April 30, 1975, when her family left for the United States. Her father, Nguyễn Cao Kỳ, was a former South Vietnamese Prime Minister, Vice President, and Air-Force General.
Kỳ Duyên currently works as a star Master of Ceremonies for Thuy Nga's Paris By Night production alongside MC Nguyen Ngoc Ngan.
Her first marriage was to Li Nguyen, a surgeon, then Trịnh Hội, a lawyer (whom she divorced in 2008). For the past 3 years, she has been publicly linked to Duy Han, a financial analyst and writer. She currently resides in Costa Mesa, California with her two daughters from her first marriage to Li Nguyen.