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O'Toole is an Irish surname. It may refer to:
- Peter O'Toole British actor (1932-2013)
- O'Tooles GAC football and hurling club in Dublin
- Ensign O'Toole, a military sitcom starring Dean Jones, which aired on NBC, 1962-1963
- Ensign O'Toole and Me, the title of a semi-autobiographical novel by William Lederer
- Plenty O'Toole, James Bond girl
- Slugger O'Toole, Irish weblog
- St. Laurence O'Toole Pipe Band
- Sneakers O'Toole Family Guy Character (Boys Do Cry)
- Timmy O'Toole Bart's fictional character who fell down a well in an episode of the Simpsons
- USS O'Toole, the name of more than one United States Navy ship
| disambiguation page lists articles associated with the title O'Toole.
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