Oligosaccaryltransferase

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Oligosaccaryltransferase
PDB 1rkl EBI.jpg
nmr structure of yeast oligosaccharyltransferase subunit ost4p
Identifiers
Symbol Ost4
Pfam PF10215
InterPro IPR018943
OPM superfamily 242
OPM protein 2lat
Membranome 465

In molecular biology, OST4 (Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 4) is a subunit of the oligosaccharyltransferase complex.[1] OST4 is a very short, approximately 30 amino acids, protein found from fungi to vertebrates. It appears to be an integral membrane protein that mediates the en bloc transfer of a pre-assembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum.[2][3]

References[edit]

  1. ^ Kelleher DJ, Gilmore R (2006). "An evolving view of the eukaryotic oligosaccharyltransferase". Glycobiology. 16 (4): 47R–62R. doi:10.1093/glycob/cwj066. PMID 16317064.
  2. ^ Gayen S, Kang C (2011). "Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex". Biochem Biophys Res Commun. 409 (3): 572–6. doi:10.1016/j.bbrc.2011.05.050. PMID 21609714.
  3. ^ Spirig U, Bodmer D, Wacker M, Burda P, Aebi M (2005). "The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast". Glycobiology. 15 (12): 1396–406. doi:10.1093/glycob/cwj025. PMID 16096346.
This article incorporates text from the public domain Pfam and InterPro: IPR018943