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PDB 1rkl EBI.jpg
nmr structure of yeast oligosaccharyltransferase subunit ost4p
Symbol Ost4
Pfam PF10215
InterPro IPR018943
OPM superfamily 242
OPM protein 2lat
Membranome 465

In molecular biology, OST4 (Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 4) is a subunit of the oligosaccharyltransferase complex.[1] OST4 is a very short, approximately 30 amino acids, protein found from fungi to vertebrates. It appears to be an integral membrane protein that mediates the en bloc transfer of a pre-assembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum.[2][3]


  1. ^ Kelleher DJ, Gilmore R (2006). "An evolving view of the eukaryotic oligosaccharyltransferase". Glycobiology. 16 (4): 47R–62R. doi:10.1093/glycob/cwj066. PMID 16317064.
  2. ^ Gayen S, Kang C (2011). "Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex". Biochem Biophys Res Commun. 409 (3): 572–6. doi:10.1016/j.bbrc.2011.05.050. PMID 21609714.
  3. ^ Spirig U, Bodmer D, Wacker M, Burda P, Aebi M (2005). "The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast". Glycobiology. 15 (12): 1396–406. doi:10.1093/glycob/cwj025. PMID 16096346.
This article incorporates text from the public domain Pfam and InterPro: IPR018943