PEA15

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Template:PBB Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.[1][2]

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[2]

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.[3]

Interactions

PEA15 has been shown to interact with Phospholipase D1,[4] Caspase 8,[5][6] MAPK1,[7] FADD[5][6] and RPS6KA3.[8]

References

  1. ^ Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC (September 1997). "Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers". Genomics. 42 (3): 540–2. doi:10.1006/geno.1997.4768. PMID 9205133.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b "Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15".
  3. ^ Böck BC, Tagscherer KE, Fassl A; et al. (July 2010). "The PEA-15 protein regulates autophagy via activation of JNK". J. Biol. Chem. 285 (28): 21644–54. doi:10.1074/jbc.M109.096628. PMC 2898427. PMID 20452983. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  4. ^ Zhang, Y (November 2000). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45). UNITED STATES: 35224–32. doi:10.1074/jbc.M003329200. ISSN 0021-9258. PMID 10926929. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  5. ^ a b Kitsberg, D (October 1999). "Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis". J. Neurosci. 19 (19). UNITED STATES: 8244–51. PMID 10493725. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  6. ^ a b Condorelli, G (August 1999). "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis". Oncogene. 18 (31). ENGLAND: 4409–15. doi:10.1038/sj.onc.1202831. ISSN 0950-9232. PMID 10442631. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  7. ^ Formstecher, E (August 2001). "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase". Dev. Cell. 1 (2). United States: 239–50. doi:10.1016/S1534-5807(01)00035-1. ISSN 1534-5807. PMID 11702783. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  8. ^ Vaidyanathan, Hema (August 2003). "RSK2 activity is regulated by its interaction with PEA-15". J. Biol. Chem. 278 (34). United States: 32367–72. doi:10.1074/jbc.M303988200. ISSN 0021-9258. PMID 12796492. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)

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