PRSS3

Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene.

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

Further reading

• Koistinen, H.; Koistinen, R.; Zhang, W. -M.; Valmu, L.; Stenman, U. -H. (2009). "Nexin-1 inhibits the activity of human brain trypsin". Neuroscience. 160 (1): 97–102. doi:10.1016/j.neuroscience.2009.02.042. PMID 19249338.
• Tani, T.; Kawashima, I.; Mita, K.; Takiguchi, Y. (1990). "Nucleotide sequence of the human pancreatic trypsinogen III cDNA". Nucleic Acids Research. 18 (6): 1631. doi:10.1093/nar/18.6.1631. PMC 330537. PMID 2326201.
• Hayashi, H.; Kohno, T.; Yasui, K.; Murota, H.; Kimura, T.; Duncan, G. S.; Nakashima, T.; Yamamoto, K.; Katayama, I.; Ma, Y.; Chua, K. J.; Suematsu, T.; Shimokawa, I.; Akira, S.; Kubo, Y.; Mak, T. W.; Matsuyama, T. (2011). "Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription". Proceedings of the National Academy of Sciences. 108 (46): 18766–18771. doi:10.1073/pnas.1116273108. PMC 3219097. PMID 22042864.
• Salameh, M. A.; Robinson, J. L.; Navaneetham, D.; Sinha, D.; Madden, B. J.; Walsh, P. N.; Radisky, E. S. (2009). "The Amyloid Precursor Protein/Protease Nexin 2 Kunitz Inhibitor Domain is a Highly Specific Substrate of Mesotrypsin". Journal of Biological Chemistry. 285 (3): 1939–1949. doi:10.1074/jbc.M109.057216. PMC 2804352. PMID 19920152.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Masson, E.; Le Maréchal, C. D.; Chen, J. M.; Férec, C. (2008). "Absence of Mesotrypsinogen Gene (PRSS3) Copy Number Variations in Patients with Chronic Pancreatitis". Pancreas. 37 (2): 227–228. doi:10.1097/MPA.0b013e3181654b6a. PMID 18665091.
• Nyaruhucha, C. N.; Kito, M.; Fukuoka, S. I. (1997). "Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance". The Journal of Biological Chemistry. 272 (16): 10573–10578. doi:10.1074/jbc.272.16.10573. PMID 9099703.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Knecht, W.; Cottrell, G. S.; Amadesi, S.; Mohlin, J.; Skåregärde, A.; Gedda, K.; Peterson, A.; Chapman, K.; Hollenberg, M. D.; Vergnolle, N.; Bunnett, N. W. (2007). "Trypsin IV or Mesotrypsin and p23 Cleave Protease-activated Receptors 1 and 2 to Induce Inflammation and Hyperalgesia". Journal of Biological Chemistry. 282 (36): 26089–26100. doi:10.1074/jbc.M703840200. PMID 17623652.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ferreira, M. A. R.; O'Donovan, M. C.; Meng, Y. A.; Jones, I. R.; Ruderfer, D. M.; Jones, L.; Fan, J.; Kirov, G.; Perlis, R. H.; Green, E. K.; Smoller, J. W.; Grozeva, D.; Stone, J.; Nikolov, I.; Chambert, K.; Hamshere, M. L.; Nimgaonkar, V. L.; Moskvina, V.; Thase, M. E.; Caesar, S.; Sachs, G. S.; Franklin, J.; Gordon-Smith, K.; Ardlie, K. G.; Gabriel, S. B.; Fraser, C.; Blumenstiel, B.; Defelice, M.; Breen, G.; Gill, M. (2008). "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder". Nature Genetics. 40 (9): 1056–1058. doi:10.1038/ng.209. PMC 2703780. PMID 18711365.
• Huntington, J. A.; Read, R. J.; Carrell, R. W. (2000). "Structure of a serpin-protease complex shows inhibition by deformation". Nature. 407 (6806): 923–926. doi:10.1038/35038119. PMID 11057674.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.