RACK protein

RACK is an acronym for receptor for activated C-kinase and is responsible for the binding of active forms of the protein kinase C (PKC) family of enzymes. See also RICK protein, Receptor for Inactive C-Kinase.

There are different RACKs for different isoforms of PKC, which thus mediate differential subcellular targeting of the isoforms.

Inactive forms of PKC occlude the RACK binding site with a pseudo-RACK peptide sequence

RACKs share 47% identity with the beta subunit of G proteins.

RACKs represent one of the many ways in which a cell can use signalling complexes to manipulate the specificity of interactions within intracellular signalling cascades.