REG3A
Template:PBB Regenerating islet-derived protein 3 alpha (also Regenerating islet-derived protein III-alpha) is a protein that in humans is encoded by the REG3A gene.[1][2]
Reg3A (UniProt Q06141) is a bactericidal C-type lectin that is constitutively produced in the intestine that has antibacterial properties against Gram-positive bacteria. Bacterial killing is mediated by binding to surface-exposed carbohydrate moieties of bacterial peptidoglycan.[3][4]
References
- ^ Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL (Jun 1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene". Genomics. 19 (1): 108–14. doi:10.1006/geno.1994.1019. PMID 8188210.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: REG3A regenerating islet-derived 3 alpha".
- ^ Cash, Heather L.; Whitham, Cecilia V.; Behrendt, Cassie L.; Hooper, Lora V. (2006-08-25). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin". Science (New York, N.Y.). 313 (5790): 1126–1130. doi:10.1126/science.1127119. ISSN 1095-9203. PMC 2716667. PMID 16931762.
- ^ Vaishnava, Shipra; Yamamoto, Miwako; Severson, Kari M.; Ruhn, Kelly A.; Yu, Xiaofei; Koren, Omry; Ley, Ruth; Wakeland, Edward K.; Hooper, Lora V. (2011-10-14). "The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine". Science (New York, N.Y.). 334 (6053): 255–258. doi:10.1126/science.1209791. ISSN 0036-8075. PMC 3321924. PMID 21998396.
Further reading
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