Rae-1 family
Retinoic acid early inducible 1 (RAE-1) family of murine cell surface glycoproteins is composed of at least five members (RAE-1α-ε).[1] Genes encoding these proteins are located on mouse chromosome 10.[1] RAE-1 proteins are related to MHC class I, they are made up of external α1α2 domain which is linked to the cell membrane by the GPI anchor.[1] They function as stress-induced ligands for NKG2D receptor and their expression is low or absent on normal cells.[1] However, they are constitutively expressed on some tumour cells and they can be upregulated by retinoic acid.[1]
References
- ^ a b c d e Cerwenka, Adelheid; Bakker, Alexander B. H.; McClanahan, Terri; Wagner, Janet; Wu, Jun; Phillips, Joseph H.; Lanier, Lewis L. (2000-01-06). "Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice". Immunity. 12 (6): 721–727. doi:10.1016/S1074-7613(00)80222-8. ISSN 1074-7613. PMID 10894171.