"React" was the lead single released from Onyx's third album, Shut 'Em Down. It featured Onyx affiliates X-1, Bonifucco and Still Livin' and a then unknown 50 Cent in his first official appearance on a song. React was released on June 2, 1998 through Def Jam Recordings and was produced by Bud'da. This was the more successful of the two singles from the album, peaking at #62 on the Hot R&B/Hip-Hop Singles & Tracks and #44 on the Hot Rap Singles. The song samples the Slick Rick song "Mona Lisa". Allmusic highlighted the song itself when they reviewed the album.