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Refugium may refer to:
- Refugium (Latin), the meaning of the word "refugium" is refuge or hideaway; in some cases known as wellness area for relaxation and recovering.
- Refugium (fishkeeping), an appendage to a marine, brackish, or freshwater fish tank that shares the same water supply
- Refugium (population biology), a location of an isolated or relict population of a once widespread animal or plant species
- Last Glacial Maximum refugia specifically, in anthropology
- Refugium Range, a mountain range on Vancouver Island, British Columbia, Canada
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