Rothberg Institute for Childhood Diseases

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The Rothberg Institute For Childhood Diseases is a non-profit organization dedicated to finding a cure for children suffering from Tuberous Sclerosis Complex, founded in 2002.[1] It was responsible for the CommunityTSC distributed computing project.

The Rothberg Institute Main Office is located in Guilford, Connecticut.

CommunityTSC[edit]

CommunityTSC Drug Design Optimization Lab (D2OL), ended on April 15, 2009, was a distributed computing project developed by the Institute to test drug candidates interaction with a target molecule that is essential to the spread of the disease under scrutiny. By evaluating the energy level released by binding a small molecule drug candidate to the surface of a larger Target molecule (D2OL) determines the fitness of the particular candidate to a region of the Target structure known as the Active Site. This process is referred to as docking the drug candidate to the target.

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