Ruzicka large-ring synthesis

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The Ruzicka large-ring synthesis or Ruzicka reaction or Ruzicka cyclization is an organic reaction in which a dicarboxylic acid is converted to a cyclic ketone at high temperature and a suitable catalyst such as thorium oxide. The reaction is named after Lavoslav Ružička, who invented it in 1926.[1]

The Ruzicka large-ring synthesis

The reaction has been applied in the synthesis of Exaltone, a synthetic Muscone.


  1. ^ L. Ruzicka; M. Stoll; H. Schinz (1926). "Zur Kenntnis des Kohlenstoffringes II. Synthese der carbocyclischen Ketone vom Zehner- bis zum Achtzehnerring". Helvetica Chimica Acta. 9 (1): 249–264. doi:10.1002/hlca.19260090130.