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Shizuo Akira

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Shizuo Akira
Born(1953-01-27)January 27, 1953
Higashiōsaka
NationalityJapanese
Alma materOsaka University
Known forToll-like receptors
AwardsSee Recognition and Awards section
Scientific career
FieldsImmunology;innate host defense mechanisms
InstitutionsDepartment of Host Defense, Osaka University, Japan.
Websitehostdefense.ifrec.osaka-u.ac.jp/en/

Shizuo Akira (審良 静男, Akira Shizuo) (born January 27, 1953 in Higashiōsaka)[1] is a professor at the Department of Host Defense, Osaka University, Japan.[2] He has made ground-breaking discoveries in the field of immunology, most significantly in the area of innate host defense mechanisms.

Beside being the world's most-cited scientist,[3] he has also been recognised, in the years 2006 and 2007, as having published the greatest number of ‘Hot Papers’ (11 papers) over the preceding two years. He is the recipient of several international awards, including the Gairdner Foundation International Award (2011), Robert Koch Prize, the Milstein Award (2007), and the William B. Coley Award.[4][5]

Among his greatest discoveries is the demonstration, through the ablation of toll-like receptor (TLR)s genes, that TLRs recognize a discrete collection of molecules of microbial origin, and later the RNA helicases, RIG-I (retinoic-acid-inducible protein I) and MDA5 (melanoma differentiation-associated protein 5).[6] All molecules belong to the pattern recognition receptors, which detects intruding pathogens and initiates antimicrobial responses in the host.[7]

Education[8]

Shizuo Akira gained a M.D. in School of Medicine from Osaka University in 1977. In 1984 he earned a PhD from Osaka University. Till 1987, he did post-doctoral research at University of California, Berkeley.

Research and career history[9]

  • Clinical Training and Physician (1977-1980)
  • Research Fellow, University of California, Berkeley (1985-1987)
  • Research Associate (1987-1995), Associate Professor (1995), Institute for Molecular and Cellular Biology, Osaka University
  • Professor, Hyogo College of Medicine (1996-1999)
  • Professor, Research Institute for Microbial Diseases, Osaka University (1999–present)
  • Center Director, Osaka University Immunology Frontier Research Center (2007–present)

Awards and honours[10] [11]

  • 2000 Inoue Prize for Science (Inoue Foundation of Science)
  • 2001 Hideyo Noguchi Prize (Osaka Science & Technology)
  • 2002 Osaka Science Prize (Osaka Science & Technology)
  • 2003 Takeda Medical Prize (Takeda Science Foundation)
  • 2004 Prize of Princess Takamatsu Cancer Research Fund
  • 2004 Robert Koch Prize (Robert Koch Foundation, Germany)
  • 2005 The Emperor's Purple Ribbon Medal (Japanese Cabinet Office)
  • 2006 Asahi Prize (Asahi Shinbun)
  • 2006 William B. Coley Award (Cancer Research Institute, USA)
  • 2007 "Hottest Researcher" Thompson Scientific Research Award
  • 2007 Uehara Prize (Uehara Memorial Foundation)
  • 2007 Imperial Prize and Japan Academy Award (Japan Academy)
  • 2007 Milstein Award (International Society for Interferon and Cytokine Research)
  • 2007 Dunham lecture at Harvard University
  • 2007 Doctor of Medical Science at Technical University of Munich
  • 2008 Dyer Lecture (National Institute of Health)
  • 2009 Marsh Lecture (The Feinstein Institute for Medical Research)
  • 2009 Lacey Lecture (Washington University at St. Louis)
  • 2009 Foreign associate, National Academy of Sciences
  • 2009 Person of Cultural Merit (Japanese Government)
  • 2009 Hans Bloemendal Medal (University of Nijmegen, Netherland)
  • 2010 Avery-Landsteiner Prize (German Society for Immunology)
  • 2010 Keio Medical Science Prize
  • 2010 Lifetime honorary member (International Endotoxin and Innate Immunity Society)
  • 2011 The Canada Gairdner International Award

Selected works

  • Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S.(1999). "Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product." J Immunol. 1999 Apr 1;162(7):3749-52. | http://www.jimmunol.org/content/162/7/3749.long | pmid=10201887 |

References

  1. ^ http://hcr3.isiknowledge.com/author.cgi?&id=5379
  2. ^ Fast Breaking Comment by Shizuo Akira, M.D., Ph.D
  3. ^ Archive - keyword 'Shizuo Akira' : Nature News
  4. ^ "Shizuo Akira M.D. 2007 Milstein Award Laureate". Milstein Awards. 2007. Retrieved May 16, 2015.
  5. ^ "Shizuo Akira MD, PhD. Recipient of the Canada Gairdner International Award, 2011". Gairdner. 2011. Retrieved May 16, 2015.
  6. ^ Yoneyama M, Kikuchi M, Natsukawa T, et al. (July 2004). "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses". Nature Immunology. 5 (7): 730–7. doi:10.1038/ni1087. PMID 15208624.
  7. ^ Lee MS, Kim YJ (February 2007). "Pattern-recognition receptor signaling initiated from extracellular, membrane, and cytoplasmic space". Molecules and Cells. 23 (1): 1–10. PMID 17464205.
  8. ^ http://hostdefense.ifrec.osaka-u.ac.jp/en/
  9. ^ http://hostdefense.ifrec.osaka-u.ac.jp/en/members/akira.html
  10. ^ https://sangakukan.jp/journal/center_contents/author_profile/akira-s_e.html
  11. ^ http://hostdefense.ifrec.osaka-u.ac.jp/en/members/akira.html
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