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Spontaneous remission

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Spontaneous remission, also called spontaneous healing or spontaneous regression, is an unexpected improvement or cure from a disease that appears to be progressing in its severity. These terms are commonly used for unexpected transient or final improvements in cancer. Spontaneous remissions concern cancers of the haematopoietic system (blood cancer, e.g. leukemia), while spontaneous regressions concern palpable tumors; however, both notions are often used interchangeably.

Definition

The spontaneous regression and remission from cancer was defined by Everson and Cole in their 1966 book as "the partial or complete disappearance of a malignant tumour in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on neoplastic disease."[1]

Frequency of spontaneous regression in cancer

It has long been assumed that spontaneous regressions, let alone cures, from cancer are rare phenomena, and that some forms of cancer are more prone to unexpected courses (melanoma, neuroblastoma, lymphoma) than others (carcinoma). Frequency was estimated to be about 1 in 100,000 cancers;[2] however, this ratio might be under- or overestimated. For one, not all cases of spontaneous regression can be apprehended, either because the case was not well documented or the physician was not willing or literate enough to publish, or simply because the patient did not show up in a clinic any more. On the other hand, for the past 100 years almost all cancer patients have been treated in one way or the other, such that the influence of treatment cannot always be excluded.

At least for small tumors the frequency of spontaneous regression most likely was drastically underrated. In a carefully designed study on mammography it was found that 22% of all breast cancer cases underwent spontaneous regression.[3]

Causes

Everson and Cole offered as explanation for spontaneous regression from cancer:

In many of the collected cases ... it must be acknowledged that the factors or mechanisms responsible for spontaneous regression are obscure or unknown in the light of present knowledge. However, in some of the cases, available knowledge permits one to infer that hormonal influences probably were important. ... In other cases, the protocols strongly suggest that an immune mechanism was responsible.[1]

Challis and Stam, even more at a loss, concluded in 1989, "In summary, we are left to conclude that, although a great number of interesting and unusual cases continue to be published annually, there is still little conclusive data that explains the occurrence of spontaneous regression."[4]

In medical circles sometimes apoptosis (programmed cell death) or angiogenesis (growth of new blood vessels) is discussed as "cause" of spontaneous regression. But both mechanisms need appropriate biochemical triggers and can not be caused on their own. To the contrary, in many cancer cells apoptosis is defective, angiogenesis is activated, both caused by mutations in cancer cells; cancer exists because both mechanisms are malfunctioning.[5]

There are several case reports of spontaneous regressions from cancer occurring after a fever brought on by infection,[2][6] suggesting a possible causal connection. If this coincidence in time would be a causal connection, it should as well precipitate as prophylactic effect, i.e. feverish infections should lower the risk to develop cancer later. This could be confirmed by collecting epidemiological studies. [7] [8]

Reviews

  • Rohdenburg (1918) summarized 185 spontaneous regressions[9]
  • Fauvet reported 202 cases between 1960–1964[10]
  • Boyd reported 98 cases in 1966[11]
  • Everson and Cole described 176 cases between 1900–1960[1][12]
  • Challis summarized 489 cases between 1900–1987[4]
  • Hobohm, in a meta-analysis, investigated about 1000 cases[2]

References

  1. ^ a b c Everson T., Cole W. (1968) Spontaneous Regression of Cancer Philadelphia, JB Saunder & Co (Book)
  2. ^ a b c Hobohm U (October 2001). "Fever and cancer in perspective". Cancer Immunol. Immunother. 50 (8): 391–6. PMID 11726133.
  3. ^ Per-Henrik Zahl; Jan Mæhlen; H. Gilbert Welch (Nov 24, 2008). "The Natural History of Invasive Breast Cancers Detected by Screening Mammography". Arch. Intern. Med. 50 (21): 2311–6. doi:10.1001/archinte.168.21.2311. PMID 19029493.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ a b Challis GB, Stam HJ (1990). "The spontaneous regression of cancer. A review of cases from 1900 to 1987". Acta Oncol. 29 (5): 545–50. doi:10.3109/02841869009090048. PMID 2206563.
  5. ^ Robert A.Weinberg: The Biology of Cancer, Garland Science 2007
  6. ^ Hobohm U (February 2005). "Fever therapy revisited". Br. J. Cancer. 92 (3): 421–5. doi:10.1038/sj.bjc.6602386. PMC 2362074. PMID 15700041.
  7. ^ Hobohm U, Stanford JL, Grange JM (2008). "Pathogen-associated molecular pattern in cancer immunotherapy". Crit. Rev. Immunol. 28 (2): 95–107. doi:10.1615/critrevimmunol.v28.i2.10. PMID 18540826.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ Maletzki C, Linnebacher M, Savai R, Hobohm U (2013). "Mistletoe lectin has a shiga toxin-like structure and should be combined with other Toll-like receptor ligands in cancer therapy". Canc.Immunol.Immunother. 62 (2): 1283–1292. doi:10.1007/s00262-013-1455-1. PMID 23832140.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Rohdenburg (1918). "Fluctuations in the growth energy of tumors in man, with esspecial reference to spontaneous recession". J Cancer Res. 3: 193–225.
  10. ^ FAUVET J, ROUJEAU J, PIET R (June 1964). "[SPONTANEOUS CANCER CURES AND REGRESSIONS]". Rev Prat (in French). 14: 2177–80. PMID 14157391.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ Boyd W: The spontaneous regression of cancer. Charles Thomas, Publ., Springfield Ill. 1966 (Book)
  12. ^ Cole WH (November 1976). "Spontaneous regression of cancer and the importance of finding its cause". Natl Cancer Inst Monogr. 44: 5–9. PMID 799760.

Further reading

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