Strecker degradation
The Strecker degradation is a chemical reaction which converts an α-amino acid into an aldehyde containing the side chain, by way of an imine intermediate. It is named after Adolph Strecker, a German chemist.
The original observation by Strecker involved the use of alloxan as the oxidant in the first step,[1] followed by hydrolysis:
The reaction can take place using a variety of organic and inorganic reagents.[2]
References
- ^ Strecker, A (1862). "Notiz über eine eigenthümliche Oxydation durch Alloxan". Annalen der Chemie und Pharmacie. 123 (2): 363–365. doi:10.1002/jlac.18621230312.
{{cite journal}}: Unknown parameter|trans_title=ignored (|trans-title=suggested) (help) - ^ Schonberg, Alexander; Moubacher, Radwan (1952). "The Strecker Degradation of α-Amino Acids". Chem. Rev. 50 (2): 261–277. doi:10.1021/cr60156a002.