Tectitethya crypta
| Tectitethya crypta | |
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| Species: | T. crypta
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| Binomial name | |
| Tectitethya crypta (de Laubenfels, 1949)
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Tectitethya crypta (formerly known as Cryptotethya crypta and Tethya crypta) is a species of demosponge belonging to the family Tethyidae.[1] It is a massive, shallow-water sponge found in the Caribbean Sea.[2][3] Oftentimes, it is covered in sand and algae.[2][3]
The nucleosides spongothymidine and spongouridine were isolated from this sponge, providing the basis for anti-viral drugs and anti-cancer drugs.[2][3] Vidarabine, an antiviral drug, was derived from these compounds.[4] The discovery of these nucleosides also led to the development of cytarabine for clinical use in the treatment of leukemia and lymphoma.[5] Gemcitabine, a fluorinated derivative of cytarabine, is used to treat pancreatic, breast, bladder, and non-small-cell lung cancer.[5]
References
- ^ http://www.marinespecies.org/aphia.php?p=taxdetails&id=170927
- ^ a b c Cerrano, Carlo; Pansini, Maurizio; Valisano, Laura; Calcinai, Barbara; Sarà, Michele; Bavestrello, Giorgio (2004). "Lagoon sponges from Carrie Bow Cay (Belize): Ecological benefits of selective sediment incorporation" (PDF). Boll. Bus. Ist. Biol. Univ. Genova. 68: 239–252. Retrieved 23 June 2012.
- ^ a b c Patricia R. Bergquist (1978). Sponges. University of California Press. p. 205. ISBN 978-0-520-03658-1. Retrieved 23 June 2012.
- ^ Sagar S, Kaur M, Minneman KP (2010). "Antiviral lead compounds from marine sponges". Mar Drugs. 8 (10): 2619–38. doi:10.3390/md8102619. PMC 2992996. PMID 21116410.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ a b Schwartsmann G, Brondani da Rocha A, Berlinck RG, Jimeno J (2001). "Marine organisms as a source of new anticancer agents". Lancet Oncol. 2 (4): 221–5. PMID 11905767.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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