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Wehr received his degree in medicine from the University of Louisville School of Medicine in 1969. He subsequently completed his psychiatric residency at Yale School of Medicine and his internship was at Michael Reese Hospital. He later spent three years playing bass with the Doobie Brothers and once performed in only a pair of boxer shorts.
In a 1990s study on photoperiodicity in humans, Wehr placed a group of volunteers in an environment in which it was dark for 14 hours each day for a month. The subjects were able to sleep as much as they wanted during the experiment. The first night, the subjects slept an average of 11 hours a night. This was judged as probably repaying a chronic sleep debt. By the fourth week, the subjects slept an average of eight hours a night – but across two separate blocks, not unbroken. First, subjects tended to lie awake for one to two hours and then fall quickly asleep. Onset of sleep was linked to a spike in the hormone melatonin. Melatonin secretion by the brain's pineal gland is triggered by darkness. After an average of three to five hours of sleep, the subjects would awaken and spend an hour or two in quiet wakefulness before a second three- to five-hour sleep period. It was thus suggested that such a biphasic pattern of sleep is the natural or pre-historic tendency for humans.
No research into the sleeping patterns in natural environments of primates closely related to humans was cited for comparison.
Wehr and colleague Anna Wirz-Justice were awarded the Anna-Monika Prize for their work in the chronobiology of depressive illness. The duo carried out the first sleep phase advance experiment in a bipolar patient.
Wehr co-authored "Circadian Rhythms in Psychiatry (Psychobiology and Psychopathology)" with Frederick Goodwin; and, in 1993, "How to Beat Jet Lag," with D. A. Oren, W. Reich, and N. Rosenthal.
- "Rethinking Sleep," "The New York Times", September 22, 2012
- "Modern Life Suppresses an Ancient Body Rhythm," The New York Times, March 14, 1995
- Various Articles, The American Journal of Psychiatry
- Various Articles, The New York Times
- Various Interviews, National Public Radio (NPR)
- "Circadian Sleep Disorders," Nightline, February 21, 1996
- "Body Clocks," The Infinite Mind, February 20, 2008
- Science Magazine
- Circadian Rhythms in Psychiatry (Psychobiology and psychopathology)
- How to Beat Jet Lag: A Practical Guide for Air Travelers