Lead-off single for the album was "Into the Fire", the music video of which received moderate play on MTV. "Into the Fire" spent eight weeks in the Top 40 of Billboard's Hot Mainstream Rock Tracks chart from October to December 1984, peaking at No. 21 and charting for a total of eleven weeks.
Second single "Just Got Lucky" was somewhat less successful, again supported by a music video while charting on the 50-place Hot Mainstream Rock Tracks chart for seven weeks during January and February 1985 and peaking at No. 27.
It would be a power ballad that would give the album—and the band—its biggest hit. "Alone Again" spent fourteen weeks on the Hot Mainstream Rock Tracks chart, including two at its peak position of No. 20. More significantly, the melodic song of heartbreak was aided by strong rotation that spring and summer at MTV and gave the band their first and biggest hit on the Hot 100, where its eleven-week run from May to July 1985 peaked at No. 64.
Though clearly more an album act than a singles act, Dokken's album sales were tied to the videos for the singles from those albums. Tooth and Nail rose to No. 71 on The Billboard 200 during the release of "Into the Fire", but fell off the charts for a week before re-entering and rising to No. 77 during the release of "Just Got Lucky". It was during the run of this single that the album, sliding down the charts after "Just Got Lucky" faded, reversed course and hit its peak of No. 49. This time, Tooth and Nail would be certified Gold by the RIAA in August 1985, the band's first certification, and would linger on the charts for the remainder of the year, aided by a gig opening for Scorpions. This continued buoying of sales resulted in the unusual circumstance of the album being rated higher on the 1985 year-end charts (No. 35) than it had actually reached in its chart peak.
The album's three music videos were later featured along with the band's other videos to date on a longform videocassette release, Unchain the Night, by Elektra/Asylum Records through Elektra Entertainment. That video debuted on Billboard's Top Music Video—Longform chart at No. 11 in January 1987, peaking at No. 5 that May. The video collection was certified Gold in April 1987, and Platinum the following April. In 2007 the collection was re-released in DVD by Rhino Home Video through Warner Music Vision, debuting on the Billboard Comprehensive Music Videos chart at No. 27.