Transplant glomerulopathy

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Transplant glomerulopathy

Transplant glomerulopathy, abbreviated TG, is a disease of the glomeruli in transplanted kidneys. It is a type of renal injury often associated with chronic antibody-mediated rejection. However, transplant glomerulopathy is not specific for chronic antibody-mediated rejection; it may be the result of a number of disease processes affecting the glomerular endothelium.[1]

Pathology

It is characterized by glomerular basement membrane thickening (referred to as tram-tracking of the basement membrane), increased mesangial matrix and segmental and global glomerulosclerosis.

The differential diagnosis of tram-tracking includes membranoproliferative glomerulonephritis (especially hepatitis C), and thrombotic microangiopathies.[1]

Additional images

  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.

See also

References

  1. ^ a b Haas, M. (Oct 2011). "Transplant glomerulopathy: it's not always about chronic rejection". Kidney Int. 80 (8): 801–3. doi:10.1038/ki.2011.192. PMID 21960169.

Signs and Symptoms [1]

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